One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, formurla is C13H11N3O5. In a document, author is Wang, Bo, introducing its new discovery. HPLC of Formula: C13H11N3O5.
Synthesis of Isofagomine Derivatives as New Fluorescence pH Indicators/Glycosidase Inhibitors
Inhibitor protonation of azasugars of the isofagomine type when bound to enzyme can be investigated using photon induced electron transfer (PET) quenching of an attached fluorophore. For this purpose, Isofagomine, iso-d-galacto-fagomine, and iso-l-gulo-fagomine were converted toN-(10-chloroanthracenenyl-9-alkyl) derivatives where the alkyl group contained one, two, or three methylene groups. The new derivatives displayed pH dependent fluorescence; as the ammonium forms they were fluorescent, while 90-99 % of the fluorescence was quenched in the amine forms. The 3 isofagomine derivatives were competitive inhibitors ofT. Maritima Iota-glucosidase withK(i)values from 0.37-4.6 tau M. Similarly, the iso-d-galacto-fagomines inhibitedA. Niger Iota-galactosidase withK(i)values from 63-2000 nm. When bound to the enzymes the inhibitors displayed between 1-15 % fluorescence.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 827026-45-9 help many people in the next few years. HPLC of Formula: C13H11N3O5.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem