One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 13925-03-6, Name is 2-Ethyl-6-methylpyrazine, formurla is C7H10N2. In a document, author is Nguyen Thi Thanh Chi, introducing its new discovery. COA of Formula: C7H10N2.
Synthesis, crystal and solution structures of platinacyclic complexes containing eugenol, the main bioactive constituent of Ocimum sanctum L. oil
The dinuclear platinacyclic complex [Pt2Cl2(Eug-1H)(2)] (1) (Eug-1H = deprotonated eugenol) has been synthesized. Reaction of 1 with amines afforded [PtCl(Eug-1H)(pyridine)] (2), [PtCl(Eug-1H)(4-Me-pyridine)] (3), [PtCl(Eug-1H)(piperidine)] (4), [PtCl(Eug-1H)(quinoline)] (5), [PtCl(Eug-1H)(NH3)] (6), [PtCl(Eug-1H)(4-Me-aniline)] (7), [PtCl(Eug-1H)(4-Cl-aniline)] (8), [Pt(Eug-1H)(8-O-quinoline)] (9) and [Pt(Eug-1H)(8-O-2-Me-quinoline)] (10). X-ray diffraction and NMR analysis show that in complexes 1-10 the chelating eugenol ligand is bound with the Pt(II) ion both through the ethylenic double bond of the allyl group and at a benzene carbon atom; in 2-10 the donor N atom of the amine is in the cis-position with respect to the ethylenic double bond. For complexes 2 and 3, two types of relatively strong highly directional intermolecular interactions are observed in the crystal packing: O-H center dot center dot center dot ClPt(II) hydrogen bonds and C-H center dot center dot center dot pi interactions, in 3 further complemented by C-H center dot center dot center dot Cl interactions. The crystal packing of 7 is dominated by dimer formation through O-H center dot center dot center dot O, N-H center dot center dot center dot Cl, C-H center dot center dot center dot Cl and C-H center dot center dot center dot pi interactions. In a d-chloroform solution of 2-5 two types of strong intermolecular interactions were detected: a Cl3C-D center dot center dot center dot ClPt(II) hydrogen bond and Cl2DC-Cl center dot center dot center dot Pt(II) halogen bond. Complex 9 exhibits significant activities on the human cancer cells KB, Hep-G2, MCF-7 and Lu, with IC50 values of 8.7, 10.8, 9.9 and 10.4 mu M respectively. (C) 2018 Elsevier Ltd. All rights reserved.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem