In an article, author is Harada, Kazuhito, once mentioned the application of 19916-73-5, Application In Synthesis of 6-(Benzyloxy)-7H-purin-2-amine, Name is 6-(Benzyloxy)-7H-purin-2-amine, molecular formula is C12H11N5O, molecular weight is 241.25, MDL number is MFCD00269931, category is piperidines. Now introduce a scientific discovery about this category.
Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure
Exploration of alternative structures of the substituted piperidine or piperazine ring which are characteristic in most of the reported GPR119 agonists provided novel spirocyclic cyclohexane derivatives. The representative 17 with a high three-dimensionality exhibited potent agonistic activity (EC50 = 4 nM) with no CYP inhibitory activity (IC50 > 10 mu M). Compound 17 also displayed hypoglycemic activity with insulin secretion dependent on glucose concentration in an intraperitoneal glucose tolerance test in rats. (C) 2018 Elsevier Ltd. All rights reserved.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem