141699-59-4, tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
B. To a cold solution (0 ¡ãC) of 4-bromo-lH-pyrazole (14.9 g, 0.10 mol) in 80 mL of dichloromethane was added sodium hydride (8.13 g, 0.20 mol) portion wise. The mixture was stirred at 0 ¡ãC for 1 hour, followed by the addition of a solution of tert-butyl 4-((methylsulfonyl)oxy)piperidine-l-carboxylate (34.0 g, 0.12 mol) in 30 mL of N,N-dimethylformamide. The resulting mixture was heated at 110 ¡ãC overnight. Purification by column chromatography afforded tert-butyl 4-(4-bromo-lH- pyrazol-l-yl)piperidine-l-carboxylate as a yellow oil in 58percent yield (19.5 g). 1H NMR (400 MHz, CDC13) delta 7.48 (s, 1H), 7.44 (s 1H), 4.35-4.20 (m, 3H), 2.95-2.85 (m, 2H), 2.15-2.05 (m, 2H), 1.92-1.81 (m, 2H), 1.48 (s, 9H)., 141699-59-4
The synthetic route of 141699-59-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SIGNALCHEM LIFESCIENCES CORPORATION; ZHANG, Zaihui; WO2015/81257; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem