Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 3056-33-5, Name is N2,9-Diacetylguanine, molecular formula is C9H9N5O3, belongs to piperidines compound. In a document, author is Songok, Abigael C., introduce the new discover, Formula: C9H9N5O3.
Structural modification of the tripeptide KPV by reductive glycoalkylation of the lysine residue
Peptides that exhibit enzymatic or hormonal activities are regulatory factors and desirable therapeutic drugs because of their high target specificity and minimal side effects. Unfortunately, these drugs are susceptible to enzymatic degradation, leading to their rapid elimination and thereby demanding frequent dosage. Structurally modified forms of some peptide drugs have shown enhanced pharmacokinetics, improving their oral bioavailability. Here, we discuss a novel glycomimetic approach to modify lysine residues in peptides. In a model system, the epsilon-amine of Ts-Lys-OMe was reductively alkylated with a glucose derivative to afford a dihydroxylated piperidine in place of the amine. A similar modification was applied to H-KPV-NH2, a tripeptide derived from the alpha-melanocyte stimulating hormone (alpha-MSH) reported to have antimicrobial and anti-inflammatory properties. Antimicrobial assays, under a variety of conditions, showed no activity for Ac-KPV-NH2 or the alpha-or epsilon-glycoalkylated analogs. Glycoalkylated peptides did, however, show stability toward proteolytic enzymes.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 3056-33-5. Formula: C9H9N5O3.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem