The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 4395-98-6, Name is 4-Cyanopiperidine, SMILES is N#CC1CCNCC1, in an article , author is Swati, once mentioned of 4395-98-6, Category: piperidines.
Design, Synthesis and Biological Evaluation of 5-amino-3-aryl-1-(6 ‘-chloropyridazin-3 ‘-yl)pyrazoles and their Derivatives as Analgesic Agents
An efficient and environmental benign solvent-free synthesis of 5-amino-3-aryl-1-(6′-chloropyridazin-3′-yl) pyrazoles (4a-e) was accomplished by grinding 3-chloro-6-hydrazinopyridazine (2) and beta-ketonitriles (3a-e) in the presence of p-toulenesulfonic acid as a catalyst. Subsequently, 6’-chloro group in 4a-e was replaced with cyclic 2 degrees amine derivatives viz. pyrrolidine 5a, piperidine 5b and morpholine 5c to obtain 6a-e, 7a-e, 8a-e respectively. The newly synthesized compounds were characterized by using IR, NMR (H-1 and C-13), mass spectral studies, elemental analyses. All the synthesized compounds were studied for their docking interaction with target protein 6COX and screened for their in vivo analgesic mode of action against swiss albino mice (animal model) using acetic-acid induced writhing test. Consequently, docking simulations data justifies the potential of synthesized series as an analgesic and very well correlated with in vivo study. Preliminary results revealed that most of the synthesized compounds exhibited moderate to good analgesic activity as compared to reference/standard drug (s) sodium diclofenac and candidates 4d and 7c protrude out as a promising lead for further investigation.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem