184637-48-7, tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Tert-butyl piperidin-3-ylcarbamate (1.027 g, 5.117 mmol) with2-bromoethyl acetate (0.712 g, 4.264 mmol) and K2CO3 (0.589 g,4.264 mmol) in acetonitrile (42 mL) was heated at reflux for 24 h.When the reaction was finished the solvent was evaporated underreduced pressure, producing a residue that was then dissolved in20 mL of ethyl acetate and washed with saturated solution ofNaHCO3 (3 x 20 mL) and saturated solution of NaCl (30 mL). Theorganic extract was dried over anhydrous Na2SO4, filtered andconcentrated under vacuum. The crude product was purified byflash column chromatography in gradient of DCM/MeOH (9.6/0.4 to9.4/0.6, v/v) yielding product 53 as an oil (0.675 g, yield 55percent). TLCDCM/MeOH (9.5/0.5, v/v) Rf 0.24. MW 286.37. Formula:C14H26N2O4. MS m/z 287.28 (M+H+). 1H NMR (300 MHz, CDCl3)delta ppm 4.94-5.09 (m, 1H), 4.18-4.22 (m, 1H), 4.11-4.18 (m, 2H),3.80-3.85 (m, 1H), 2.43-2.61 (m, 4H), 2.26-2.42 (m, 2H), 2.05 (s,3H), 1.47-1.62 (m, 3H), 1.43 (s, 9H)., 184637-48-7
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Reference£º
Article; Panek, Dawid; Wi?ckowska, Anna; Wichur, Tomasz; Bajda, Marek; Gody?, Justyna; Jo?czyk, Jakub; Mika, Kamil; Janockova, Jana; Soukup, Ondrej; Knez, Damijan; Korabecny, Jan; Gobec, Stanislav; Malawska, Barbara; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 676 – 695;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem