4395-98-6, Name is 4-Cyanopiperidine, molecular formula is C6H10N2, Computed Properties of C6H10N2, belongs to piperidines compound, is a common compound. In a patnet, author is Fazylov, S. D., once mentioned the new application about 4395-98-6.
CATALYZED BY PALLADIUM COMPLEXES THE CYCLOADDITION OF HYDRAZONES TO FULLERENEC60
The article is devoted to the development of a preparatively convenient method for the synthesis of new methanofullerenes by the catalytic cyclo coupling of hydrazones to fullereneC(60). The catalyst used was Pd(acac)(2)-PPh3-AlEt3. The reactions were carried out under conditions of generating substituted diazomethanes in situ by oxidation of the hydrazones of the corresponding aldehydes with MnO2. The use of complexes of transition metals in this reaction makes it possible to direct the cycloaddition of the diazo compounds to fullerenes towards the production of individual methanofullerenes. Initially, the synthesis of the initial arylhydrazones by the interaction of substituted benzaldehydes (salicylic aldehyde, 5-bromosalicyl aldehyde, 4-morpholino-benzaldehyde, 4-piperidine benzaldehyde) with an excess of hydrazine hydrate in isopropyl alcohol was carried out. The reaction of the reaction of diazoarylaldehydes with fullerene C-60 was monitored by HPLC. It is shown that the use of the catalyst Pd(acac)(2)-PPh3-AlEt3 in a ratio of 1:4:4 leads to the formation of exclusively methanofullerenes with yields of 40-95%. The composition and purity of the methanofullerenes obtained are confirmed by MALDI-TOF and HPLC mass spectrometry, and the structure by (NMRH)-H-1 spectroscopy. The mechanism of formation of methanofullerene is discussed.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem