Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Shashi, R., once mentioned the application of 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, molecular formula is C12H9N5O, molecular weight is 239.23, MDL number is MFCD00037927, category is piperidines. Now introduce a scientific discovery about this category, Name: N-(7H-Purin-6-yl)benzamide.
One-Pot Synthesis of 1,4-Dihydropyridine Derivatives and Their X-Ray Crystal Structures: Role of Fluorine in Weak Interactions
1,4-dihydropyridines, namely diethyl 4-(4-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(1a), diethyl 2,6-dimethyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate(1b), and diethyl 4-(3,4-dimethoxyphenyl)-2,6-dihydroxy-2,6-bis(trifluoromethyl)piperidine-3,5-dicarboxylate(2), are synthesized by one-pot multicomponent condensation of aromatic aldehyde with ethyl acetoacetate and liquid ammonia in the presence of an ethanol-water mixture and are characterized by single crystal X-ray diffraction. The effect of a fluorine atom on the dihydropyridine nucleus give insight into the self-assembly of compounds with various types of non-covalent interactions that greatly affect the crystal packing.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem