Chemistry, like all the natural sciences, COA of Formula: C6H12ClN, begins with the direct observation of nature¡ª in this case, of matter.5570-77-4, Name is 4-Chloro-1-methylpiperidine, SMILES is CN1CCC(CC1)Cl, belongs to piperidines compound. In a document, author is Zhao, Bosheng, introduce the new discover.
Click-Addressable Cassette for Photoaffinity Labeling
A small molecule 1 was designed to contain an alkyne, a trifluoromethyl phenyldiazirine, and a free piperidine-NH for facile conjugation to protein binding ligands. This cassette 1 was synthesized via a relatively direct route involving only routine steps. In this proof-of-concept study, putative ligands for carbonic anhydrase IX and for TrkC were conjugated to 1. Photoaffinity labeling was performed using purified extracellular regions of both these protein-receptors, and using cells that express these receptors (isolation via a pull-down procedure), labeling of the protein was observed in all four experiments.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5570-77-4. COA of Formula: C6H12ClN.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem