Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.10465-81-3, Name is Diazene-1,2-diylbis(piperidin-1-ylmethanone), SMILES is O=C(/N=N/C(N1CCCCC1)=O)N2CCCCC2, belongs to piperidines compound. In a document, author is Sattar, Almas, introduce the new discover, Recommanded Product: Diazene-1,2-diylbis(piperidin-1-ylmethanone).
Synthesis of new antibacterial agents encompassing tosyl, piperidine, propanamide and 1,3,4-oxadiazole functionalities
A series of propanamide compounds 6a-1 was derived by N-substitution reactions, encompassing tosyl, piperidine and 1,3,4-oxadiazole moieties. The intended array of compounds 6a-1 was afforded by a series of five steps reaction scheme. 1-Tosylpiperidin-4-carboxylate (1) was synthesized by the reaction of tosyl chloride (a) with ethyl isonipecotate (b) under mild basic conditions. Compound 1 was subjected to nucleophillic substitution by hydrazine to synthesize 1-tosylpiperidin-4-carbohydrazide (2). The compound, 5-(1-tosylpiperidin-4-yl)-1,3,4-oxadiazole-2-thiol (3) was synthesized by intermolecular cyclization of compound 2 by CS2 under strong basic conditions. The target compounds, 6a-1, were finally synthesized from 3 by reacting with different electrophiles, 5a-1, in an aprotic polar solvent with sodium hydride as an activator. The different propanamoyl electrophiles, 5a-1, were synthesized by the reaction of different aromatic and aliphatic amines, 4a-1, with 3-bromopropionyl chloride under mild basic conditions. The structural elucidation was carried out using modern spectroscopic techniques including IR, H-1-NMR and EI-MS. The antibacterial potential of synthesized compounds was assessed against five bacterial strains. Compounds 6a, 6c, 6d, 6e and 6f were found to be potent antibacterial agents.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10465-81-3 is helpful to your research. Recommanded Product: Diazene-1,2-diylbis(piperidin-1-ylmethanone).
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem