The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, in an article , author is Teno, Naoki, once mentioned of 88495-54-9, Recommanded Product: 88495-54-9.
Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists
Famesoid X receptor (FXR) plays a major role in the control of cholesterol metabolism. Antagonizing transcriptional activity of FXR is an effective means to treat the relevant metabolic syndrome. Some of antagonists so far have the charged functions; however, they may negatively affect the pharmacokinetics. We describe herein a structure activity relationship (SAR) exploration of nonacidic FXR antagonist 6 focusing on two regions in the structure and biological evaluation of nonacidic 10 with the characteristic N-acylated piperidine group obtained from SAR studies. As the robust affinity to FXR is feasible with our nonacidic analogue, 10 is among the most promising candidates for in vivo testing.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem