Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 3-Ethyl-2,5-dimethylpyrazine, 13360-65-1, Name is 3-Ethyl-2,5-dimethylpyrazine, molecular formula is C8H12N2, belongs to piperidines compound. In a document, author is Muthukumaran, Panchaksaram, introduce the new discover.
MIA-QSAR based model for bioactivity prediction of flavonoid derivatives as acetylcholinesterase inhibitors
Alzheimer’s disease is a common form of dementia, which considered to be a major health concern. Multivariate Image Analysis – Quantitative Structure-Activity Relationship (MIA-QSAR) is a simple and quite accessible QSAR method for predicting biological activities of unstudied compounds based on 20 image analysis. This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). The model was constructed by PLS (Partial Least Square) using NIPALS (Non-Linear iterative Partial Least Square) algorithm. The comparable values obtained from calibration of training set using five latent variables (R-2 = 0.955) and external validation of test set (Q(2) = 0.948) confirmed the precision in the prediction of bioactivities for the set of flavonoid derivatives used in designing the model. (C) 2018 Elsevier Ltd. All rights reserved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 13360-65-1. Recommanded Product: 3-Ethyl-2,5-dimethylpyrazine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem