Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 105812-81-5, 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, molecular formula is C13H18FNO, belongs to piperidines compound. In a document, author is Ashraf, Muhammad Awais, introduce the new discover.
Diastereoselective Reductive Cyclization of Allene-Tethered Ketoamines via Copper-Catalyzed Cascade Carboboronation and Protodeborylation
A copper-catalyzed cascade process has been developed for the synthesis of 3-hydroxypyrrolidine derivatives in a highly diastereoselective manner. The reaction proceeded via borylative allyl copper intermediate formation from allenes; the intermediate underwent intramolecular diastereoselective cyclization followed by cascade copper-catalyzed protodeborylation, to give 3-hydroxypyrrolidines. This method could be extended to the synthesis of six-membered piperidine analogs. A series of control experiments were carried out to confirm the Cu-catalyzed facile protodeborylation of borylated homoallylic alcohols at room temperature.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 105812-81-5. Product Details of 105812-81-5.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem