Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, in an article , author is Jevtic, Ivana I., once mentioned of 401566-79-8, Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.
Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines
Background 4-Anilidopiperidine class of synthetic opioid analgesics, with it’s representative fentanyl, are by far the most potent and clinically significant for the treatment of the severe chronic and surgical pain. However, side effects of mu-opioids are often quite serious. In order to improve the pharmacological profile of this class of opioid analgesics, a novel fentanyl analogs were designed, synthesized and evaluated in vivo for their antinociceptive activity. Methods The title compounds were prepared using known synthetic transformations, includingN-bromoacetamide mediated Hofmann rearrangement, highly selective carbamate cleavage with trimethylsilyl iodide and dehydration of carboxamide group to nitrile in the presence of SOCl2. The antinociceptive activity of the synthesized compounds was determined by tail-immersion and formalin test. Results The scalable synthetic route towards novel fentanyl analogs bearing nitrogen groups in position C(3)of piperidine ring is designed. In addition, Hofmann rearrangement was substantially improved for the more efficient synthesis of previously published 3-substituted fentanyl analogs. The series of ten fentanyl analogs was tested in vivo for their antinociceptive activity. The most potent compound of the series was found to becis-4, based on the determined ED(50)values in tail-immersion test. Conclusion Of ten compounds tested for their antinociceptive activity, compoundcis-4is characterized by high potency, rapid beginning and short duration of action and due to this might be incorporated in different pharmaceutical forms.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 401566-79-8, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem