#REF!
A facile one-pot synthesis of 1H-pyrano[2,3-d]pyrimidin-4(5H)-ones and evaluation of their Ct-DNA interaction, antibacterial and anti-inflammatory activity
In this paper, we reported the synthesis of coumarin-pyrimidine derivatives by a four-component reaction involving 4-hydroxycoumarin, aldehyde, thiobarbituric acid and piperidine in ethanol. All the synthesized compounds were well-characterized by IR, NMR and mass spectroscopic techniques. Further, to evaluate the biological potency of the synthesized compounds, initially, DNA cleavage studies were performed. Encouraged by the results obtained from the cleavage studies, the synthesized compounds were screened for in-vitro antibacterial and anti-inflammatory activity. From the biological activity results, it revealed that most of the synthesized compounds were found to exhibit potent antimicrobial and anti-inflammatory activity with least IC50 than compared with standard.
If you are hungry for even more, make sure to check my other article about 10310-21-1, COA of Formula: C5H4ClN5.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem