Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, SDS of cas: 827026-45-9, 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, SMILES is [O-][N+](=O)C1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1, belongs to piperidines compound. In a document, author is Chen, Weijie, introduce the new discover.
Rapid functionalization of multiple C-H bonds in unprotected alicyclic amines
The preparation of unprotected alicyclic amines containing variable substituents in multiple ring positions typically requires multistep synthetic sequences. Now, an advance in C-H bond functionalization methodology that enables the convenient preparation of elusive endocyclic 1-azaallyl anions allows the introduction of up to three substituents in a single operation. The synthesis of valuable bioactive alicyclic amines containing variable substituents in multiple ring positions typically relies on multistep synthetic sequences that frequently require the introduction and subsequent removal of undesirable protecting groups. Although a vast number of studies have aimed to simplify access to such materials through the C-H bond functionalization of feedstock alicyclic amines, the simultaneous introduction of more than one substituent to unprotected amines has never been accomplished. Here we report an advance in C-H bond functionalization methodology that enables the introduction of up to three substituents in a single operation. Lithiated amines are first exposed to a ketone oxidant, generating transient imines that are subsequently converted to endocyclic 1-azaallyl anions, which can be processed further to furnish beta-substituted, alpha,beta-disubstituted, or alpha,beta,alpha ‘-trisubstituted amines. This study highlights the unique utility of in situ-generated endocyclic 1-azaallyl anions, elusive intermediates in synthetic chemistry.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 827026-45-9. SDS of cas: 827026-45-9.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem