Electric Literature of 13925-03-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 13925-03-6, Name is 2-Ethyl-6-methylpyrazine, SMILES is CC1=CN=CC(CC)=N1, belongs to piperidines compound. In a article, author is Akentieva, N. P., introduce new discover of the category.
Anticancer Activity of Spirocyclic Hydroxamic Acids (Derivatives of 1-Hydroxy-1,4,8-Triazaspiro[4,5]Decan-2-One), Histone Deacetylase Inhibitors
Ten racemic spirocyclic hydroxamic acids (CHA 1-10, 1-hydroxy-1,4,8-triazaspiro [4,5]decan-2-one derivatives) containing pharmacophore imidazolidine and piperidine fragments with various substituents were synthesized. It was shown that CHA (1-10) are inhibitors of the activity of the histone deacetylase enzyme in cultured breast cancer cells. The study of antitumor activity in vivo CHA (1-10) showed that in polychemotherapy with cisplatin and cyclophosphamide these compounds possess pronounced chemosensitizing antitumor activity and increase the life span of experimental animals. Thus, it is shown that spirocyclic hydroxamic acids possess therapeutic potential in polychemotherapy for the treatment of oncological diseases.
Electric Literature of 13925-03-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 13925-03-6.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem