Synthetic Route of 622-26-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 622-26-4, Name is 2-(Piperidin-4-yl)ethanol, SMILES is OCCC1CCNCC1, belongs to piperidines compound. In a article, author is Khan, Momin, introduce new discover of the category.
2-Indolinone Derivatives as Potent Urease Inhibitors
Background: 2-Indolinone is a bicycle, heterocyclic compound analogous of indole skeleton containing a carbonyl group at 2-position of the 5-membered ring. Recently, different biological evaluations of oxindole derivatives have been reported. A variety of compounds with oxindoles moiety exhibit useful pharmaceutical properties like anti-inflammatory, anti-bacterial, anticancer, anti-proliferative, anti-hypertensive, anti-HIV and anti-convulsant activities. Methods: In the present study, fifteen 6-chloro-3-oxindole derivatives (1-15) were screened for urease inhibitory activity. The binding mode of the synthesized compounds was studied by molecular docking and found good results. 6-Chloro-3-oxindole derivatives 1-15 were synthesized from 6-chlorooxindole by refluxing with different aromatic aldehydes in ethanol in the presence of piperidine in high yields. Docking was carry out of the ligands into HCV NS3/4A protein. The software package MOE (Molecular Operating Environment) was used for docking. Results: Our present study has shown that compound 6 (IC50 = 13.34 +/- 1.75 mu M), 2 (IC50 = 16.67 +/- 1.73 mu M), and 5 (IC50 = 17.85 +/- 2.21 mu M) were found to be the most potent urease inhibitors as compared to the standard thiourea (IC50 = 21.1 +/- 0.11 mu M). Conclusion: Our present study has shown that Compounds 6 (IC50 = 13.34 +/- 1.75 mu M), 2 (IC50 = 16.67 +/- 1.73 mu M), and 5 (IC50 = 17.85 +/- 2.21 mu M) were found to be the most potent urease inhibitors as compared to the standard thiourea (IC50 = 21.1 +/- 0.11 mu M). These may serve as lead compounds for better urease inhibitors after fine tuning in the structure and further studies in future.
Synthetic Route of 622-26-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 622-26-4 is helpful to your research.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem