Electric Literature of 120013-39-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 120013-39-0, Name is 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride, SMILES is Cl.COC2=C(C=C1C(C(CC1=C2)CC3CCNCC3)=O)OC, belongs to piperidines compound. In a article, author is de Lucas, Ana Isabel, introduce new discover of the category.
Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu(2) Receptor PAMs
Starting from two weak mGlu(2) receptor positive allosteric modulator (PAM) HTS hits (4 and 5), a molecular hybridization strategy resulted in the identification of a novel spiro-oxindole piperidine series with improved activity and metabolic stability. Scaffold hopping around the spiro-oxindole core identified the 3(azetidin-3-yl)-1H-benzimidazol-2-one as bioisoster. Medicinal chemistry optimization of these two novel chemotypes resulted in the identification of potent, selective, orally bioavailable, and brain penetrant mGluR(2) PAMs.
Electric Literature of 120013-39-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 120013-39-0.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem