Interesting scientific research on 4-Chloro-1-methylpiperidine

Application of 5570-77-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5570-77-4.

Application of 5570-77-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5570-77-4, Name is 4-Chloro-1-methylpiperidine, SMILES is CN1CCC(CC1)Cl, belongs to piperidines compound. In a article, author is Ramya, R., introduce new discover of the category.

In silico investigation of quorum quenching potential of Piper nigrum, Piper betle and Coscinium fenestratum on Vibrio cholerae

Current study investigates the ability of phytoligands to inhibit biofilm formation in multidrug resistant, clinically isolated V. cholerae. Methanolic extracts of Coscinium fenestratum, Piper betle and Piper nigrum were checked for their antibiofilm activity. The herbal bioactive compounds were screened by LC/MS-MS and binding potentials against the drug targets were predicted by molecular docking. The extracts exhibited a MIC in a range of 0.1mg/mL- 0.15mg/mL. Reduction of EPS and rhamnolipids was found to be 84.27%, 67% and 46.6% respectively by C. fenestratum, P. betle and P. nigrum. Six major proteins were selected as putative targets. Of the 6 targets, the phytoligands were effective against AphB, HapR, LuxO and Vps. Berberine present in C. fenestratum (binding energy of -8.6 kcal/mol), Eugenol in P. betle (binding energy – 6.2 kcal/mol) and Piperidine in P. nigrum (binding energy -4.0 kcal/mol) demonstrated effective minimum binding energy against AphB. In silico analysis has revealed that the QS proteins of V. cholerae targeted by the phytoligands might destabilize the biofilm on density dependent manner based on inhibition of surface adhesion and attenuating the virulence factors leading to quorum sensing inhibition. Berberine and Eugenol can be used as quorum inhibitors for attenuation of MDR V. cholerae at sub inhibitory concentration of 50 mu g/mL.

Application of 5570-77-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5570-77-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem