Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 119515-38-7, Name is sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate, molecular formula is C12H23NO3, belongs to piperidines compound, is a common compound. In a patnet, author is Zhu, Yinghuai, once mentioned the new application about 119515-38-7, Category: piperidines.
Synthesis, reactivity, in vitro boron neutron capture therapy assay, and molecular docking of fluorocyclocarboxyboranylamine
The one-pot reaction of Me3NBH2CN with Et3O+BF4- followed by addition of BF3 center dot Et2O and water produces a trimethylamine derivative of fluorocyclocarboxyboranylamine, Me3NBH2C(O2BF2NH2) (1) in 36.0% yield. Compound 1 undergoes exchange reaction between the exo-Me3N moiety and piperidine or pyridine to produce the corresponding piperidine-substituted fluorocyclocarboxyboranylamine (2) or pyridine-substituted fluorocyclocarboxyboranylamine (3) in 51.2% or 42.4% yields, respectively. The new compounds were characterized by H-1, C-13, B-11, and F-19 nuclear magnetic resonance spectroscopy; Fourier-transform infrared spectroscopy; and elemental analyses and the crystal structure of 1 was determined to confirm its molecular geometry. The in vitro killing effects of 1, along with its toxicity measurements and molecular docking interactions with matrix metalloproteinases showed a potential promise of such species as both boron neutron capture therapy and boron neutron capture synovectomy agents in the treatment of tumors and rheumatoid arthritis, respectively, in the presence of slow neutrons.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 119515-38-7. The above is the message from the blog manager. Category: piperidines.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem