14691-88-4, 4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of this acid (110 mg, 0.296 mmol, crude) in dry DCM (3.5 mL) at 0 C. were added successively a solution of 4-amino-TEMPO (78.4 mg, 0.444 mmol) in dry DCM (0.5 mL), DMAP (40.2 mg, 0.326 mmol), HOBt.H2O (44.0 mg, 0.326 mmol) and EDCI (69.5 mg, 0.355 mmol). The resulting orange solution was stirred at room temperature under argon for 13 h, and then washed with sat. NH4Cl. The aqueous phase was separated and extracted once with DCM, and the combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo. Flash chromatography (SiO2, EtOAc to 97:3, EtOAc/MeOH) afforded 91.2 mg (59%) of the title compound as an orange oil which solidified very slowly upon high vacuum. mp 168.0-168.8 C. (softening point: -75 C.); [alpha]D23 -14.1 (c 0.5, DCM); EIMS m/z 525 ([M+H]+, 10), 371 (27), 218 (28), 201 (74), 124 (100), 91 (35), 84 (26); HRMS (EI) n/z calcd for C30H43N3O3P 524.3042, found 524.3040., 14691-88-4
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Reference£º
Patent; University of Pittsburgh – Of the Commonwealth System of Higher Education; Epperly, Michael W.; Gao, Xiang; Greenberger, Joel S.; Li, Song; Wipf, Peter; (63 pag.)US2019/210969; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem