147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of l-N-t-Boc-4-methyIamino piperidine (1.0458 g, 4.88 mmol) and mPEG3-Br (1 .2490 g, 5.50 mmol) and potassium carbonate (1.8871 g, 13.65 mmol) in water (2.0 mL) in a vial was heated at 120 ¡ãC for 1.5 h by using microwave. The mixture was diluted with water, extracted with dichloromethane (3 x 30 mL). The combined organic solution was washed with brine, dried over anhydrous sodium sulfate, concentrated. The residue was dried under high vacuum. The residue was separated with flash column chromatography on silica gel using 1-5percent methanol in dichloromethane to afford product (1.2531 g) as oil in 78percent yield. NMR (500 MHz, Chloroform-*/) delta 4.1 1 (s, 2H), 3.65 – 3.56 (m, 6H), 3.55 – 3.49 (m, 4H), 3.35 (s, 3H), 2.63 (br, 2H), 2.62 (t, J = 6.2 Hz, 2H), 2.49 (m, 1 H), 2.27 (s, 3H), 1.70 (d, J = 12.7 Hz, 2H), 1.42 (s, 9H), 1.44 – 1.30 (m, 2H). MS for C 18H36 2O5: 361.2 (MH+)., 147539-41-1
147539-41-1 tert-Butyl 4-(methylamino)piperidine-1-carboxylate 15380702, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
Piperidine – Wikipedia
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