71486-53-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71486-53-8,Methyl 4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.
A mixture of 20 gm (103.3 mMol) methyl 4-oxo-3-piperidinecarboxylate hydrochloride and 75 mL saturated aqueous sodium bicarbonate in 150 mL dichloromethane was stirred vigorously at room temperature. A solution of 24.8 gm (113.6 mMol) di-tert-butyl dicarbonate in 100 mL dichloromethane was then added dropwise over three hours. After stirring at room temperature for about 16 hours, an additional 3.0 gm di-tert-butyl dicarbonate were added and stirring continued for an additional 2 hours. The reaction mixture was then diluted with water and extracted with 2 x 250 mL dichloromethane. The organic phases were combined, dried over magnesium sulfate, and concentrated under reduced pressure to provide 26.2 gm (99percent) of the desired compound as a yellow oil.
The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELI LILLY AND COMPANY; EP1204659; (2003); B1;,
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