With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.896464-16-7,tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate,as a common compound, the synthetic route is as follows.
Step A: tert-butyl 2-(5 -(methylsulfonyl)pyrazin-2-yl)-2,7-diazaspiro [3.5 lnonane-7-carboxvlate:A mixture of tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate (commercially available from numerous vendors, for example, AstaTech, Inc., catalog 52326; 75 mg, 0.33 mmol), 2-Chloro- 5-(methylsulfonyl)pyrazine (64 mg, 0.33 mmol), Pd2(dba)3 (15 mg, 0.0 17 mmol), X-Phos (24 mg, 0.050 mmol), K3P04 (140 mg, 0.66 mmol), and dioxane (1.7 mL) in a microwave tube was heated to 120 C under an atmosphere of nitrogen for 12 minutes. The reaction was diluted withEtOAc, washed with brine, dried over Na2504, and concentrated. The crude product was purified by silica gel chromatography to furnish the title compound. LCMS: m/z 383 (M+H), 896464-16-7
The synthetic route of 896464-16-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
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