Synthetic Route of 145508-94-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.145508-94-7, Name is tert-Butyl 4-(iodomethyl)piperidine-1-carboxylate, molecular formula is C11H20INO2. In a Patent£¬once mentioned of 145508-94-7
INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 145508-94-7 is helpful to your research. Synthetic Route of 145508-94-7
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H23594N – PubChem