Final Thoughts on Chemistry for 88763-76-2

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One-pot parallel synthesis approach to secondary amines based on the reductive amination of ketones

A combination of a condensation mixture [a Lewis acid, Ti(Oi-Pr) 4, and a water scavenger, 1-(trimethylsilyl)-2-pyrrolidinone] and a simple reductant (NaBH4) provides an efficient one-pot approach to parallel synthesis of secondary amines by the reductive amination of ketones. The approach demonstrated its applicability to a variety of substrates with different degree of hindrance of an amino or a carbonyl group affording products in moderate to high yields. Georg Thieme Verlag Stuttgart New York.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H1673N – PubChem