With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.957855-54-8,4-Amino-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide,as a common compound, the synthetic route is as follows.
957855-54-8, General procedure: Dimethyl (4-aminobenzyl)phosphonate (1.1 equiv), X-phos (0.1equiv) and Cs2CO3 (3.0 equiv) in 1,4-dioxane, and Pd(AcO)2 (0.05equiv) were added to solutions of compounds 10a-h (1 equiv) undera nitrogen atmosphere. The mixture was purged with nitrogenfor 5 min and then heated at 90 C until the reactionwas complete.The mixture was diluted with ethyl acetate, and the organic layerwas washed with saline, dried over anhydrous Na2SO4, filtered andconcentrated. The residue was purified using column chromatographyto afford compounds 11a-h.
The synthetic route of 957855-54-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chen, Yixuan; Cheng, Maosheng; Hao, Chenzhou; Wang, Ruifeng; Wu, Tianxiao; Yang, Bowen; Yu, Sijia; Zhao, Dongmei; Zhao, Xiangxin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Piperidine – Wikipedia
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