Extended knowledge of 8-Boc-2,8-Diazaspiro[4.5]decane

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.236406-39-6. In my other articles, you can also check out more blogs about 236406-39-6

Reference of 236406-39-6, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 236406-39-6, name is 8-Boc-2,8-Diazaspiro[4.5]decane. In an article£¬Which mentioned a new discovery about 236406-39-6

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity

The substitution of 6-fluoroquinolines was modified in ring positions 2 and 4. The new compounds were tested in vitro for their activities against a sensitive and a multidrug resistant strain of Plasmodium falciparum. Some physicochemical parametres were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability). The most promising compounds were tested for their in vivo activity against Plasmodium berghei in a mouse model. The 6-fluoro-2-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-N-[2-(pyrrolidin-1-yl)ethyl]quinoline-4-carboxamide possessed proper physicochemical properties and showed high antiplasmodial activity in vitro (IC50 ? 0.0029 muM) and in vivo (99.6% activity).

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H19371N – PubChem