Chemistry is an experimental science, Computed Properties of C6H11NO2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 25137-00-2, Name is (R)-Piperidine-3-carboxylic acid
Orally active and potent inhibitors of gamma-aminobutyric acid uptake
3-Pyrrolidineacetic acid (1a), certain piperidinecarboxylic acids – i.e., 3-piperidinecarboxylic acid (2a), 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (3a), and cis-4-hydroxy-3-piperidinecarboxylic acid (4a) – cis-3-aminocyclohexanecarboxylic acid (5a, cis-3-ACHC), and gamma-aminobutyric acid (6a, GABA) itself are among the most potent inhibitors of [3H]GABA uptake by neurons and glia in vitro. These hydrophilic amino acids, however, do not readily enter the central nervous system in pharmacologically significant amounts following peripheral administration. We now report that N-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid is a specific GABA-uptake inhibitor that is more potent, more lipophilic and, in limited testing, as selective as 2a. Similar results were obtained with the N-(4,4-diphenyl-3-butenyl) derivatives of 1a, 3a, and 4a. By contrast, N-(4,4-diphenyl-3-butenyl) derivatives of 5a and 6a were not more potent than the parent amino acids and appear to inhibit GABA uptake, at least in part, by a nonselective mechanism of action. The N-(4,4-diphenyl-3-butenyl)amino acids exhibit anticonvulsant activity in rodents following oral or intraperitoneal administration.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C6H11NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 25137-00-2, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H5082N – PubChem