A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of N-(2-Aminoethyl)piperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 27578-60-5, Name is N-(2-Aminoethyl)piperidine, molecular formula is C7H16N2. In a Article, authors is Peng, Wang£¬once mentioned of 27578-60-5
Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex
The human proto-oncogene neuroblastoma RAS (NRAS) contains a guanine-rich sequence in the 5?-untranslated regions (5?-UTR) of the mRNA that could form an RNA G-quadruplex structure. This structure acts as a repressor for NRAS translation and could be a potential target for anticancer drugs. Our previous studies found an effective scaffold, the quindoline scaffold, for binding and stabilizing the DNA G-quadruplex structures. Here, on the basis of the previous studies and reported RNA-specific probes, a series of novel p-(methylthio)styryl substituted quindoline (MSQ) derivatives were designed, synthesized, and evaluated as NRAS RNA G-quadruplex ligands. Panels of experiments turned out that the introduction of p-(methylthio)styryl side chain could enhance the specific binding to the NRAS RNA G-quadruplex. One of the hits, 4a-10, showed strong stabilizing activity on the G-quadruplex and subsequently repressed NRAS’s translation and inhibited tumor cells proliferation. Our finding provided a novel strategy to discover novel NRAS repressors by specifically binding to the RNA G-quadruplex in the 5?-UTR of mRNA.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 27578-60-5, help many people in the next few years.Application In Synthesis of N-(2-Aminoethyl)piperidine
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H4317N – PubChem