Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 137076-22-3, molcular formula is C11H19NO3, introducing its new discovery. name: tert-Butyl 4-formylpiperidine-1-carboxylate
Stereoselective synthesis of cyclopropanes based on a 1,2-chirality transfer
A stereoselective route to enantiomerically enriched bicyclic cyclopropane derivatives 13 is described which is based on a conceptually novel 1,2-chirality transfer approach. The hyperconjugative interaction of an electronically excited carbonyl group with the sigma* orbital of an adjacent C-X bond in the transition state of a hydrogen abstraction causes the preference of a certain conformation and consequently the differentiation between two diastereotopic methylene groups. The 1,2-chirality transfer is completed by a subsequent HX elimination which destroys the only stereogenic center in the reactants 12. Furthermore, it was found that contrary enthalpic and entropic influences result in the existence of an inversion temperature T0. Upon crossing T0 the stereoselectivity is reversed. Considering this temperature dependency, chirality transfer efficiencies of up to 83% could be achieved. The absolute configuration of most products could be unambiguously determined by VCD spectroscopy combined with DFT calculations.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: tert-Butyl 4-formylpiperidine-1-carboxylate, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 137076-22-3
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H16464N – PubChem