Reference of 41979-39-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 41979-39-9, Name is Piperidin-4-one hydrochloride, molecular formula is C5H10ClNO. In a Article£¬once mentioned of 41979-39-9
Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents
A novel series of maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones were prepared to investigate the efficacy of micronutrient conjugation in enhancing cytotoxic potency by improving selectivity and delivery. These compounds, prepared as anticancer agents, were expected to demonstrate enhanced selectivity towards malignant cells through the inhibition of topoisomerase IIalpha via protein thiolation. The cytostatic effects of these compounds were evaluated against three cell lines, namely murine L1210 leukemia cells, human Molt 4/C8 and CEM T-lymphocyte cells. All compounds were found to have greater potency than the reference drug melphalan. Several compounds were found to potently inhibit topoisomerase IIalpha and displayed cytostatic activity in the nanomolar range.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Reference of 41979-39-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 41979-39-9, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6236N – PubChem