Synthetic Route of 10314-98-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.10314-98-4, Name is N-Cbz-4-Piperidinecarboxylic acid, molecular formula is C14H17NO4. In a article£¬once mentioned of 10314-98-4
Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation
Autotaxin (ATX) is a potential target for the treatment of various cancers. A new series of ATX inhibitors was rationally designed and synthesized based on our previous study. Biological evaluation and structure-activity relationship (SAR) of this series are discussed. Among fourteen synthesized derivatives, six compounds (2, 3, 4, 12, 13 and 14) exhibited enhanced ATX inhibitory activities with IC50 values in the low nanomolar range. Molecular interactions of all the synthesized compounds within the active site of ATX were studied through molecular docking studies. Herein, we describe our lead optimization efforts that resulted in the identification of a potent ATX inhibitor (compound 4 with IC50 = 1.23 nM, FS-3 and 2.18 nM, bis-pNPP). Furthermore, pharmacokinetic properties of this most promising compound are profiled.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10314-98-4, and how the biochemistry of the body works.Synthetic Route of 10314-98-4
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H21545N – PubChem