The important role of N,N-Dimethylpiperidin-4-amine

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 50533-97-6

Related Products of 50533-97-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.50533-97-6, Name is N,N-Dimethylpiperidin-4-amine, molecular formula is C7H16N2. In a Article£¬once mentioned of 50533-97-6

5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta: Optimization of enzymatic and functional activity

PKCtheta is a serine/threonine kinase involved in the regulation of IL2 production in T cells. It has recently become an attractive therapeutic target for a variety of immunological disorders. We describe the optimization of the enzymatic and cellular potency of a series of 5-vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta. A binding model was developed that explains much of the SAR observed for this series, including the enzymatic potency observed for 19. An analysis of functional potency against various physiochemical parameters suggests that cellular potency is correlated with Log D7.4, but not with c Log P, PAMPA permeability, or TPSA.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H3875N – PubChem