A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of tert-Butyl 4-formylpiperidine-1-carboxylate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 137076-22-3, Name is tert-Butyl 4-formylpiperidine-1-carboxylate, molecular formula is C11H19NO3. In a Article, authors is George, Dawn M.£¬once mentioned of 137076-22-3
Discovery of selective and orally bioavailable protein kinase CI? (PKCI?) inhibitors from a fragment hit
Protein kinase CI? (PKCI?) regulates a key step in the activation of T cells. On the basis of its mechanism of action, inhibition of this kinase is hypothesized to serve as an effective therapy for autoimmune diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis. Herein, the discovery of a small molecule PKCI? inhibitor is described, starting from a fragment hit 1 and advancing to compound 41 through the use of structure-based drug design. Compound 41 demonstrates excellent in vitro activity, good oral pharmacokinetics, and efficacy in both an acute in vivo mechanistic model and a chronic in vivo disease model but suffers from tolerability issues upon chronic dosing.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 137076-22-3, help many people in the next few years.Application In Synthesis of tert-Butyl 4-formylpiperidine-1-carboxylate
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H16305N – PubChem