91419-48-6, tert-Butyl 4-carbamoylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4-CARBAMOYL-PIPERIDINE-L-CARBOXYLIC acid TERT-BUTYL ester (2) (45.4 g, 0.199 mol), Lawesson’s reagent (40.2 g, 0.099 mol, 0.5 equiv), 1,2-dimethoxyethane (DME) (500 mL) and chloroform (200 mL) were combined and stirred at room temperature. The course of the reaction was followed by tlc analysis (30% ethyl ACETATE/HEXANE) and on completion the reaction mixture was evaporated to dryness (glassy solid). The solid was dissolved in ethyl acetate and washed with half saturated potassium carbonate solution, dried (MGSO4), filtered and concentrated to yield the title compound as a colourless solid. The crude product was crystallised from ethyl acetate and hexane to give the title compound (3) (35 g, 0.14 mol, 72%).
As the paragraph descriping shows that 91419-48-6 is playing an increasingly important role.
Reference£º
Patent; METRIS THERAPEUTICS LIMITED; WO2004/58750; (2004); A1;,
Piperidine – Wikipedia
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