Synthetic Route of 50533-97-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 50533-97-6, Name is N,N-Dimethylpiperidin-4-amine, molecular formula is C7H16N2. In a Article£¬once mentioned of 50533-97-6
Design and synthesis of imidazole and triazole derivatives as Lp-PLA 2 inhibitors and the unexpected discovery of highly potent quaternary ammonium salts
New Lp-PLA2 inhibitors were synthesized by the bioisosteric replacement of the amide group of Darapladib with an imidazole or a triazole. Unfortunately, the inhibitory activities of these derivatives were lower than that of Darapladib. But interestingly, a series of quaternary ammonium salts that were isolated as by-products during this synthetic work were found with high potency. Of these by-products, compound 22c showed a similar profile to Darapladib both in vitro and in vivo.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 50533-97-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50533-97-6, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H3890N – PubChem