Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes was written by Kim, Heung Jae;Kwak, Woo Young;Min, Jong Pil;Lee, Jae Young;Yoon, Tae Hyun;Kim, Ha Dong;Shin, Chang Yell;Kim, Mi Kyung;Choi, Song Hyen;Kim, Hae Sun;Yang, Eun Kyoung;Cheong, Ye Hwang;Chae, Yu Na;Park, Kyung Jin;Jang, Ji Myun;Choi, Soo Jung;Son, Moon Ho;Kim, Soon Hoe;Yoo, Moohi;Lee, Bong Jin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.SDS of cas: 78551-60-7 This article mentions the following:
A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229, I) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clin. development. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate (cas: 78551-60-7SDS of cas: 78551-60-7).
tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate (cas: 78551-60-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.SDS of cas: 78551-60-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics