Das, Biswajit et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2005 | CAS: 154590-34-8

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Related Products of 154590-34-8

Synthesis and SAR of novel oxazolidinones: Discovery of ranbezolid was written by Das, Biswajit;Rudra, Sonali;Yadav, Ajay;Ray, Abhijit;Rao, A. V. S. Raja;Srinivas, A. S. S. V.;Soni, Ajay;Saini, Suman;Shukla, Shalini;Pandya, Manisha;Bhateja, Pragya;Malhotra, Sunita;Mathur, Tarun;Arora, S. K.;Rattan, Ashok;Mehta, Anita. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Related Products of 154590-34-8 This article mentions the following:

Novel oxazolidinones, e.g. I (R = H, CHO, CO2H, HON:CH, CN, Cl, etc.), containing a number of substituted five-membered heterocycles attached to the piperazinyl-phenyl-oxazolidinone core of eperezolid, were synthesized. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible Gram-pos. organisms, along with the identification of ranbezolid I (R = O2N) (RBx 7644) as a clin. candidate. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8Related Products of 154590-34-8).

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Related Products of 154590-34-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics