Synthesis and inhibitory activity on carbonic anhydrase of some new sulpiride analogs studied by means of a new method was written by Botre, Claudio;Botre, Francesco;Jommi, Giancarlo;Signorini, Roberto. And the article was included in Journal of Medicinal Chemistry in 1986.Computed Properties of C7H14N2 This article mentions the following:
The pharmacol. activity of new sulpiride analogs was studied by a potentiometric technique with a pCO2 sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions. This procedure gives results state as percent of inhibition of enzymic activity. To prove the reliability of the approach and to study structure-activity relationships, several new mols., e.g., sulfamoylbenzamides I (R = Et2NCH2CH2, 2-piperidinoethyl, morpholinoethyl) and piperazine amides II (R1 = H, allyl, Me2CHCH2, EtO2CCH2, PhCH2, etc.) were prepared and tested in comparison with the two sulpiride enantiomers. An inhibition mechanism is discussed in terms of exptl. evidence obtained from the interactions between the mol. structures of the new synthesized compounds and carbonic anhydrase. In the experiment, the researchers used many compounds, for example, (S)-1,4-Diazabicyclo[4.3.0]nonane (cas: 93643-24-4Computed Properties of C7H14N2).
(S)-1,4-Diazabicyclo[4.3.0]nonane (cas: 93643-24-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Computed Properties of C7H14N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics