Clinical observation of dexzopiclone combined with tandospirone citrate in treatment of patients with hypertension complicated with anxiety was written by Wang, Na;Liu, Hua-ling. And the article was included in Linchuang Huicui in 2013.Application In Synthesis of rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate This article mentions the following:
Objective: To observe the therapy effect of dexzopiclone combined with tandospirone citrate in treatment of patients with hypertension complicated with anxiety. Methods: 120 patients with hypertension complicated with anxiety were randomly divided into group A (40 cases), group B (40 cases) and group C (40 cases). The patients in group A administrated lacidipine, and the patients in group B administrated tandospirone citrate and lacidipine. The patients in group C administrated dexzopiclone, tandospirone citrate and lacidipine. SBP, DBP and Hamilton anxiety scale (HAMA) were observed before therapy and 8 wk after therapy. Results: Before therapy, the difference in SBP, DBP and HAMA score had no statistical significance among the three groups. After therapy, SBP, DBP and HAMA score in group B and group C had obvious decrease as compared with before therapy (P < 0.05 or P < 0.01). After therapy, SBP and DBP in group B and group C were lower than in group A (P < 0.01). The DBP in group C was lower than group B (P < 0.01). The HAMA score in group C after therapy was lower than in group A and group B (P < 0.01). The difference in adverse reaction had no statistical significance among the three groups (χ2 = 0.721, P > 0.05). Conclusion: Hypertension has close correlation with anxiety and insomnia, and in clin. working, we not only need to pay attention to control of hypertension and also need to change the psychol. disease and complicated related symptom of patients to well control blood pressure, prevent target organ injury and improve survival rate. In the experiment, the researchers used many compounds, for example, rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1Application In Synthesis of rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate).
rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Application In Synthesis of rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics