Synthetic Route of 111153-74-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.111153-74-3, Name is 1-Phenylpiperidine-4-carbaldehyde, molecular formula is C12H15NO. In a Article£¬once mentioned of 111153-74-3
beta1-Selective Adrenoceptor Antagonists. 1. Synthesis and beta-Adrenergic Blocking Activity of a Series of Binary (Aryloxy)propanolamines
A series of binary (aryloxy)propanolamines has been prepared and examined in vitro and in vivo for beta-adrenoreceptor blocking activity.These symmetrical compounds consist of two (S)-(phenyloxy)propanolamine pharmacophores coupled through alkylenedioxy or poly(oxyethylenedioxy) linking units of varying lengths.Examples of such binary compounds linked through the 2,2′, 3,3′, and 4,4′ positions in the aromatic rings of the pharmacophores have been prepared.In vitro and in vivo test data indicate that the 2,2′ compounds tend to be selective beta2-adrenergic blocking agents, the 4,4′ binaries tend to be selective beta1-blocking agents, and those compounds with 3,3′ linkages exhibit intermediate selectivities.One of the 4,4′-linked binary compounds, 4s, exhibited potent, cardioselective beta-blockade in vivo, which was of short duration and was accompanied by a prolonged tachycardia.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 111153-74-3
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H11783N – PubChem