Spatial consequences of blocking mTOR/S6K relevance for therapy was written by Rosner, Margit;Schipany, Katharina;Hengstschlaeger, Markus. And the article was included in Cell Cycle in 2012.HPLC of Formula: 1255517-76-0 This article mentions the following:
This article highlights the recent data illustrating that different inhibitors cause distinct spatial redistributions of their targets, and that this might be of relevance for their usage in therapy. It concentrates on the effects of blocking mammalian target of rapamycin (mTOR)/S6 kinase (S6K). It is of intriguing relevance for their therapeutic usage to provide a detailed mol. investigation of the tumor, including the spatial regulation of both the drug targets and their substrates, causatively involved in the transformation process. Therapeutic approaches involving the well-directed, selective application of a single drug or the combined usage of various drugs to compensate for adverse side effects due to unintended subcellular redistribution could largely benefit from individual, tumor-specific spatial profiling of transformation-inducing and -promoting targets and from knowledge of the spatial consequences of target inhibition. In the experiment, the researchers used many compounds, for example, 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole (cas: 1255517-76-0HPLC of Formula: 1255517-76-0).
2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole (cas: 1255517-76-0) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.HPLC of Formula: 1255517-76-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics