Jansen, Michaela et al. published their research in Journal of Medicinal Chemistry in 2008 | CAS: 280110-69-2

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine (cas: 280110-69-2) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Product Details of 280110-69-2

Synthesis of GABAA Receptor Agonists and Evaluation of their 伪-Subunit Selectivity and Orientation in the GABA Binding Site was written by Jansen, Michaela;Rabe, Holger;Strehless, Axelle;Dieler, Sandra;Debus, Fabian;Dannhardt, Gerd;Akabas, Myles H.;Lueddens, Hartmut. And the article was included in Journal of Medicinal Chemistry in 2008.Product Details of 280110-69-2 This article mentions the following:

Drugs used to treat various disorders target GABAA receptors. To develop 伪 subunit selective compounds, we synthesized 5-(4-piperidyl)-3-isoxazolol (4-PIOL) derivatives The 3-isoxazolol moiety was substituted by 1,3,4-oxadiazol-2-one , 1,3,4-oxadiazol-2-thione, and substituted 1,2,4-triazol-3-one heterocycles, e.g. I (R = 4-piperidyl, 2-pyrrolidinyl, H2NCH2CH2, etc., X = O, S, Y = O; R = 4-piperidinyl, H2NCH2, X = O, S, Y = PhCH2N), with modifications to the basic piperidine substituent as well as substituents without basic nitrogen. Compounds were screened by [3H]muscimol binding and in patch-clamp experiments with heterologously expressed GABAA 伪i尾3纬2 receptors (i = 1-6). The effects of 5-aminomethyl-3H-[1,3,4]oxadiazol-2-one were comparable to GABA for all 伪 subunit isoforms. 5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-one and 5-piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione (II) were weak agonists at 伪2-, 伪3-, and 伪5-containing receptors. When coapplied with GABA, they were antagonistic in 伪2-, 伪4-, and 伪6-containing receptors and potentiated 伪3-containing receptors. II protected GABA binding site cysteine-substitution mutants 伪1F64C and 伪1S68C from reacting with methanethiosulfonate-ethylsulfonate. II specifically covalently modified the 伪1R66C thiol, in the GABA binding site, through its oxadiazolthione sulfur. These results demonstrate the feasibility of synthesizing 伪 subtype selective GABA mimetic drugs. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine (cas: 280110-69-2Product Details of 280110-69-2).

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine (cas: 280110-69-2) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Product Details of 280110-69-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem