General procedure for the synthesis of spirocyclic 3-hydroxy- and 3-oxotetrahydrofurans containing carbo- and heterocyclic fragments was written by Moskalenko, A. I.;Belopukhov, S. L.;Ivlev, A. A.;Boev, V. I.. And the article was included in Russian Journal of Organic Chemistry in 2011.Product Details of 203662-51-5 This article mentions the following:
Reactions of cyclopentanone, cyclohexanone, N-substituted pyrrolidin-3-one and piperidin-4-one, and tetrahydropyran-4-one with allyl bromide in the presence of zinc and ammonium chloride gave the corresponding geminal hydroxy allyl derivatives Treatment of the latter with sodium periodate in the presence of sodium metabisulfite resulted in their oxidative cyclization with formation of oxa spirocyclic alcs. containing carbo- and heterocyclic fragments. Swern oxidation of the spiro alcs. afforded the corresponding ketones which were characterized as 2,4-dinitrophenylhydrazones. In the experiment, the researchers used many compounds, for example, 4-Allyl-1-Boc-4-hydroxypiperidine (cas: 203662-51-5Product Details of 203662-51-5).
4-Allyl-1-Boc-4-hydroxypiperidine (cas: 203662-51-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Product Details of 203662-51-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem