Straightforward and scalable synthesis of orthogonally protected 3,7-diazabicyclo[4.1.0]heptane was written by Schramm, Heiko;Pavlova, Maria;Hoenke, Christoph;Christoffers, Jens. And the article was included in Synthesis in 2009.Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane This article mentions the following:
Orthogonally N-protected (Boc and Cbz) 3,4-aziridinopiperidine is a versatile building block for the synthesis of 4-substituted 3-aminopiperidines, which are compounds with a high potential for biol. activity. A multigram synthesis over five steps, starting with extraordinarily simple materials (pyridine and benzyl chloride), was developed. In the experiment, the researchers used many compounds, for example, N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane).
N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane (cas: 66207-08-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: N-Cbz-7-oxa-3-azabicyclo[4.1.0]heptane
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem