Solubility of Racemic Paroxetine Intermediate in Supercritical Carbon Dioxide was written by Bao, Zong-Bi;Wei, Zuo-Jun;Su, Bao-Gen;Ren, Qi-Long. And the article was included in Journal of Chemical & Engineering Data in 2006.SDS of cas: 109887-53-8 This article mentions the following:
The solubility of racemic paroxetine intermediate in supercritical carbon dioxide was measured in the pressure range from (9 to 24) MPa and at temperatures of (308.2, 318.2, and 328.2) K using a continuous flow-type apparatus equipped with a high-pressure UV-Vis detector. Results showed that under the present operation conditions, the exptl. determined solubility of the racemic compound was in the range of (7.3 脳 10-5 to 1.2 脳 10-3) in mole fraction. The solubility increased with rising pressure at constant temperature, and the crossover pressure was found to locate at around 12 MPa for the three solubility isotherms. An empirical d.-based Chrastil’s equation was used to fit the exptl. solubility data, giving a good correlation with an AARD of 7.56 %. In the experiment, the researchers used many compounds, for example, ((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8SDS of cas: 109887-53-8).
((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 109887-53-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem