Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity was written by Arita, Tsuyoshi;Asano, Masayoshi;Kubota, Kazufumi;Domon, Yuki;Machinaga, Nobuo;Shimada, Kousei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Name: (S)-tert-Butyl 3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate This article mentions the following:
We synthesized derivatives of a natural alkaloid, conolidine I, and evaluated these derivatives in the acetic acid-induced writhing test and formalin test in ddY mice after oral administration. As a result, we identified (5S)-6-methyl-1,3,4,5,6,8-hexahydro-7H-2,5-methano[1,5]diazonino[7,8-b]indol-7-one sulfate salt, II (DS54360155), with a unique and original bicyclic skeleton, as an analgesic more potent than conolidine. Moreover, II did not exhibit mu-opioid receptor agonist activity. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl 3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate (cas: 1002360-09-9Name: (S)-tert-Butyl 3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate).
(S)-tert-Butyl 3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate (cas: 1002360-09-9) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Name: (S)-tert-Butyl 3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem